PRODUCT CLASSIFICATION
產(chǎn)品分類HMGBiotech 高遷移率蛋白、質(zhì)粒、抗體
HMGBiotech公司簡介
HMGBiotech公司研發(fā)的HMGB 1是細(xì)胞核的一個(gè)組成部分,在基因組的組織和表達(dá)中具有多種功能。HMG生物技術(shù)SRL為活躍在這一領(lǐng)域的其他研究人員和公司提供試劑、服務(wù)和想法。它還有助于比安奇實(shí)驗(yàn)室開發(fā)分析和試劑。
HMGBiotech是一家生物技術(shù)公司,由HMGB領(lǐng)域的 ling xian 科學(xué)家Marco E. Bianchi創(chuàng)立。
HMGBiotech是唯yi一家生產(chǎn)HMGB1質(zhì)量控制氧化還原變體的生產(chǎn)商。 該公司為活躍于這一有前途領(lǐng)域的其他研究人員和公司提供試劑、服務(wù)和想法,并幫助 Bianchi 實(shí)驗(yàn)室開發(fā)檢測方法和試劑。
HMGB1是細(xì)胞核的一個(gè)組成部分,在基因組的組織和表達(dá)中具有多種功能。當(dāng)細(xì)胞因損傷(病毒、機(jī)械或化學(xué)創(chuàng)傷、中毒)而死亡時(shí),HMGB1 被釋放并被附近細(xì)胞中的受體吸收。此外,處于嚴(yán)重壓力下的細(xì)胞甚至在死亡前就會(huì)分泌HMGB1。存活的細(xì)胞會(huì)發(fā)出一線反應(yīng) - 炎癥 - 并試圖替換死細(xì)胞并重建受損組織。HMGB1 促進(jìn)恢復(fù)和再生,例如梗死后心臟的恢復(fù)和再生。然而,過多的 HMGB1 與膿毒癥(過度炎癥導(dǎo)致急性痛苦并最終死亡)、關(guān)節(jié)炎、動(dòng)脈粥樣硬化和癌癥轉(zhuǎn)移有關(guān)。
anti HMGB1單克隆抗體
小鼠單克隆 IgG1 DPH1.1 是通過向 C57BL/6 小鼠注射 17 聚體肽 P1 (KGKPDAAKKGVVKAEKS) 產(chǎn)生的。雜交瘤通過標(biāo)準(zhǔn)技術(shù)從脾細(xì)胞中產(chǎn)生,并通過 ELISA 針對(duì)免疫原和全長 HMGB1 進(jìn)行測試。
DPH1.1 mAb 可識(shí)別所有哺乳動(dòng)物 HMGB1,包括人、小鼠和大鼠。無法識(shí)別 HMGB2。
DPH1.1 mAb 可用于蛋白質(zhì)印跡 (WB)。
DPH1.1 mAb 在跨孔遷移試驗(yàn)中阻斷 HMGB1 誘導(dǎo)的細(xì)胞遷移。
在體內(nèi),靜脈內(nèi)施用 DPH1.1 mAb (220 μg/小鼠) 可阻斷炎癥細(xì)胞募集到壞死和感染部位。
本產(chǎn)品僅供研究使用,不能用于人體。
HMGBiotech公司熱銷產(chǎn)品
產(chǎn)品名稱 | 貨號(hào) | 規(guī)格 |
100 ug Fully reduced HMGB1, LPS free | HM-115 | 100 ug |
50 ug Fully reduced HMGB1, LPS free | HM-116 | 50 ug |
100 ug Disulfide HMGB1, LPS free | HM-121 | 100 ug |
100 ug BoxA from HMGB1, LPS-free and tested in migration assay | HM-012 | 100 ug |
50 ug Disulfide HMGB1, LPS free | HM-122 | 50 ug |
500 ug BoxA from HMGB1, LPS-free and tested in migration assay | HM-013 | 500 ug |
1 mg HMGB1 for biochemistry | HM-100 | 1 mg |
2.5 mg BoxA from HMGB1, LPS-free and tested in migration assay | HM-014 | 2.5 mg |
250 ug HMGB1 biochemistry | HM-101 | 250 ug |
25 ug BoxA from HMGB1, LPS-free and tested in migration assay | HM-011 | 25 ug |
15 ug BoxB from HMGB1, LPS-free and tested in migration assay | HM-053 | 15 ug |
15 ug Fully reduced HMGB1, LPS free | HM-117 | 15 ug |
10 ug Disulfide HMGB1, LPS free | HM-123 | 10 ug |
15 ug Non-oxidizable HMGB1, LPS free | HM-133 | 15 ug |
250 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in migration | HM-170 | 250 ug |
100 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in migration | HM-171 | 100 ug |
50 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in migration | HM-172 | 50 ug |
15 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in migration | HM-173 | 15 ug |
50 ug HMGB1 15N labelled for Mass Spectrometry | HM-180 | 50 ug |
5 ug HMGB1 15N labelled for Mass Spectrometry | HM-181 | 5 ug |
2.5 mg BoxA 2D from HMGB1, LPS-free and tested in migration assay | HM-190 | 2.5 mg |
500 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay | HM-191 | 500 ug |
100 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay | HM-192 | 100 ug |
25 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay | HM-193 | 25 ug |
Control cell lysates from Hmgb1 +/+ | HM-001 | 請(qǐng)咨詢 |
Control cell lysates from Hmgb1 -/- | HM-002 | 請(qǐng)咨詢 |
1 mg BoxB from HMGB1, LPS-free and tested in migration assay | HM-050 | 1 mg |
250 ug BoxB from HMGB1, LPS-free and tested in migration assay | HM-051 | 250 ug |
100 ug BoxB from HMGB1, LPS-free and tested in migration assay | HM-052 | 100 ug |
500 ug Fully reduced HMGB1, LPS free | HM-114 | 500 ug |
250 ug Disulfide HMGB1, LPS free | HM-120 | 250 ug |
500 ug Non-oxidizable HMGB1, LPS free | HM-130 | 500 ug |
100 ug Non-oxidizable HMGB1, LPS free | HM-131 | 100 ug |
50 ug Non-oxidizable HMGB1, LPS free | HM-132 | 50 ug |
500 ug HMGB2, LPS-free and tested in migration assay | HM-151 | 500 ug |
100 ug HMGB2, LPS-free and tested in migration assay | HM-152 | 100 ug |
50 ug HMGB2, LPS-free and tested in migration assay | HM-153 | 50 ug |
Embryonic fibroblasts immortalized with large T antigen. One vial of -/- cells and one vial of +/+ cells | HM-201 | 2管 |
Embryonic fibroblasts immortalized with the 3T3 method. One vial of -/- cells and one vial of +/+ cells | HM-221 | 2管 |
Embryonic fibroblasts, Hmgb1-/- and HMGB2-low, immortalized with the 3T3 method. One vial of cells, and | HM-223 | 2管 |
HMGB1 Isoforms Kit - Test size | HM-030 | 請(qǐng)咨詢 |
Embryonic fibroblasts immortalized with the 3T3 method. One vial of Hmgb2-/- cells and one vial of +/+ cells | HM-251 | 2管 |
HMGB1 Isoforms Kit - Regular size | HM-031 | 請(qǐng)咨詢 |
20 ug p-mHMG1 | HM-300 | 20 ug |
50 ug Terminally oxidized HMGB1, LPS free | HM-062 | 50 ug |
20 ug p-mHMG1tag | HM-301 | 20 ug |
100 ug Terminally oxidized HMGB1, LPS free | HM-061 | 100 ug |
20 ug pEGFP-HMGB1 | HM-302 | 20 ug |
250 ug Terminally oxidized HMGB1, LPS free | HM-060 | 250 ug |
20 ug pcDNA/FL-RAGE plasmid | HM-310 | 20 ug |
郵箱:1804548568@qq.com
傳真:86-010-62817090
地址:北京市昌平區(qū)城北街道鼓樓東街33號(hào)6號(hào)樓6428室